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With increasing needs of fast and reliable commu- nication between devices, wireless communication techniques are rapidly evolving to meet such needs. Multiple input and output (MIMO) systems are one of the key techniques that utilize multiple antennas for high-throughput and reliable communication. However, increasing the number of antennas in communication also adds to the complexity of channel esti- mation, which is essential to accurately decode the transmitted data. Therefore, development of accurate and efficient channel estimation methods is necessary. We report the performance of machine learning-based channel estimation approaches to enhance channel estimation performance in high-noise envi- ronments. More specifically, bit error rate (BER) performance of 2 × 2 and 4 × 4 MIMO communication systems with space- time block coding model (STBC) and two neural network-based channel estimation algorithms is analyzed. Most significantly, the results demonstrate that a generalized regression neural network (GRNN) model matches BER results of a known-channel communication for 4 × 4 MIMO with 8-bit pilots, when trained in a specific signal to noise ratio (SNR) regime. Moreover, up to 9dB improvement in signal-to-noise ratio (SNR) for a target BER is observed, compared to least square (LS) channel estimation, especially when the model is trained in the low SNR regime. A deep artificial neural network (Deep ANN) model shows worse BER performance compared to LS in all tested environments. These preliminary results present an opportunity for achieving better performance in channel estimation through GRNN and highlight further research topics for deployment in the wild.